background

Anti-CSF-1R Monoclonal Antibody

Anti-CSF-1R mAb

background

Source: Kitko et al. J Clin Oncol. 2022;41:1864-1875.

 

The CSF-1/CSF-1R pathway is a key pathway in chronic GVHD that regulates monocyte proliferation and macrophage differentiation and activity.1 CSF-1R signaling is critical for development and function of alternatively polarized macrophages, which can exert profibrotic and inflammatory functions. In chronic GVHD, monocytes and macrophages can mediate inflammation and fibrosis, inducing tissue damage.2,3,4 By inhibiting CSF-1R signaling, macrophage- and monocyte-dependent pathways involved with both inflammation and fibrosis, hallmarks of chronic GVHD progression, can be suppressed.

 


References:

  1. Hume and Macdonald. Blood. 2012;119:1810-1820.
  2. Alexander et al. J Clin Invest. 2014;124:4266-4280.
  3. MacDonald et al. Blood. 2017;129:13-21.
  4. Jardine et al. J Clin Invest. 2020;130:4574-4586.